N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este

N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este - Names and Identifiers

Name	N-Boc-Trans-4-Hydroxy-D-Proline Methyl Ester
Synonyms	Boc-trans-D-Hyp-OMe Boc-trans-4-Hydroxy-D-proline Methyl ester N-Boc-trans-4-Hydroxy-D-prolinemethyl ester N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER N-Boc-Trans-4-Hydroxy-D-Proline Methyl Ester (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 1-tert-Butyl 2-methyl (2R,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate (2S,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 1,2-pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S)- 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)- (2R,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-Methyl ester (N-Boc-trans-4-Hydroxy-D-proline Methyl ester
CAS	135042-17-0
EINECS	828-101-2
InChI	InChI=1/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8+/m0/s1

N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este - Physico-chemical Properties

Molecular Formula	C11H19NO5
Molar Mass	245.27
Density	1.216±0.06 g/cm3 (20 ºC 760 Torr)
Boling Point	335.2±42.0 °C(Predicted)
Flash Point	156.6°C
Vapor Presure	8.47E-06mmHg at 25°C
pKa	14.27±0.40(Predicted)
Storage Condition	2-8°C
Refractive Index	1.5

N-Boc-Trans-4-Hydroxy-D-Proline Methyl Este - Introduction

N-BOC-trans-4-hydroxy-D-proline methyl ester is an organic compound. The following is an introduction to its nature, use, preparation and safety information:

Nature:
N-BOC-trans-4-hydroxy-D-proline methyl ester is a solid substance. Its chemical formula is C11H19NO5 and its molecular weight is 245.27. The compound has a trans configuration and has a hydroxyl group and a methyl ester group at the 4-position, with a protecting group BOC on the amino group. It is a white or yellowish crystal with a high decomposition temperature.

Use:
N-BOC-trans-4-hydroxy-D-proline methyl ester is a commonly used organic synthesis intermediate. It is commonly used in drug synthesis and natural product synthesis as an intermediate for the introduction and removal of amino acid protecting groups. It can also be used as a protecting group of proline for more chemical modifications and reactions.

Preparation Method:
N-BOC-trans-4-hydroxy-D-proline methyl ester can be synthesized by a variety of methods. One commonly used method is the reaction of trans-4-hydroxy-D-proline with BOC-formic acid under basic conditions to form N-BOC-trans-4-hydroxy-D-proline methyl ester.

Safety Information:
N-BOC-trans-4-hydroxy-D-proline methyl ester has certain safety under general use conditions. However, care should be taken to avoid prolonged contact with the skin and inhalation of its dust. Appropriate personal protective equipment, such as lab gloves and safety glasses, should be worn during operation. In addition, it needs to be stored properly and away from ignition and oxidizing agents. Specific safe operation recommendations and treatment methods should refer to the relevant safety data form or consult a chemical expert.

Last Update：2024-04-09 20:52:54